2013 Fiscal Year Final Research Report
Attempt to control ARE-mRNA expressed in oral cancer cells
| Project/Area Number |
24659883
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Surgical dentistry
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| Research Institution | Hokkaido University |
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Principal Investigator |
SATOH Chiharu 北海道大学, 大学病院, 講師 (50222013)
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| Co-Investigator(Kenkyū-buntansha) |
SHINDO Masanobu 北海道大学, 大学院歯学研究科, 教授 (20162802)
HIGASHINO Fumihiro 北海道大学, 大学院歯学研究科, 准教授 (50301891)
KITAMURA Tetsuya 北海道大学, 大学院歯学研究科, 助教 (00451451)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | 口腔がん / ARE-mRNA / pp32 |
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| Research Abstract |
In this study, we examined the features of pp32 in order to develop the cancer therapy utilizing the control of pp32 expression in oral cancer cells. Over-expression of pp32 down-regulated the anchorage-independent growth activity of oral cancer cells. On the other hand, the knock-down of pp32 inhibited the export and stabilization of ARE-mRNA and conferred the anchorage-independent growth ability for oral cancer cells.
These results indicate that the pp32 expression changes the features of oral cancer cells and that the possibility of the cancer therapy using pp32 over-expression.
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