2015 Fiscal Year Final Research Report
Application of gene database for the treatment of cleft palate
| Project/Area Number |
24659890
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Surgical dentistry
|
|---|
| Research Institution | Osaka University |
|---|
Principal Investigator |
SAKAI TAKAYOSHI 大阪大学, 歯学研究科(研究院), 教授 (90379082)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
NOHARA KANJI 大阪大学, 大学院歯学研究科, 准教授 (20346167)
|
|---|
| Project Period (FY) |
2012-04-01 – 2016-03-31
|
| Keywords | 口蓋裂 |
|---|
| Outline of Final Research Achievements |
Our purpose of this study is to understand the mechanism of palatal fusion for cleft palate treatment. Gene expression database was created and applied for the discovery of genes that related to palatal fusion.Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) was identified from database and increased during and after palatal fusion. Quantitative real-time PCR confirmed the increase of CEACAM1. Functional antibody of CEACAM1 inhibited palatal fusion. CEACAM1 could be important for palatal fusion. These data regarding the interaction of CEACAM1 and palatal development would be used for future treatment of cleft palate.
|
| Free Research Field |
医歯薬学
|
