The role of new protein complex, so called 'degradosome' produced by cariogenic microorganism, results to be effective to the environment.

2014 Fiscal Year Final Research Report

• Project/Area Number: 24659911
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Orthodontic/Pediatric dentistry
• Research Institution: Hiroshima University
• Principal Investigator: KOZAI Katsuyuki 広島大学, 大学院医歯薬保健学研究院, 教授 (10178212)
• Co-Investigator(Kenkyū-buntansha): MITSUHATA Chieko 広島大学, 大学院医歯薬保健学研究院, 准教授 (10335664) ; OHHARA Yukari 広島大学, 大学院医歯薬保健学研究院, 助教 (80634469)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: mutans streptococci / 齲蝕 / 細菌の生育環境 / デグラドゾーム / 環境適応

Outline of Final Research Achievements

The purpose of this study is to make sure that the formation of multiprotein complex called degradosome and the control should be performed as a method of adaptation of living environment in biofilm of cariogenic mutans streptococci. Firstly, the experiment of seeking some protein producing MS complex of a center of enolase was performed. The cDNA was made by cloning of enolase and recognition of DNA sequence was done. The results showed that the point mutation was found to UA159 in all strains. In two starins, it is found that some amino acids are different.

Free Research Field

小児歯科学