2013 Fiscal Year Final Research Report
Molecular dissection of periodontal susceptibility for generation of predictive dentistry
| Project/Area Number |
24659933
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Social dentistry
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| Research Institution | Osaka University |
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Principal Investigator |
AMANO Atsuo 大阪大学, 歯学研究科(研究院), 教授 (50193024)
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| Co-Investigator(Kenkyū-buntansha) |
KUBONIWA Masae 大阪大学, 歯学部附属病院, 講師 (00303983)
FURUTA Nobumichi 大阪大学, 大学院歯学研究科, 助教 (50452446)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | Porphyromonas gingivalis / 細胞内感染 / 歯周炎 / SNARE / 小胞輸送 |
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| Research Abstract |
We analyzed microbicidal molecular basis against intercellular pathogens in periodontal cells in order to evaluate host susceptibility to periodontitis for future predictive dentistry.
Following the entry to gingival epithelial cells, P. gingivalis is sorted to early endosomes, and the half of the intracellular pathogens are transported to recycling pathway via SNARE protein, VAMP2, which allows the bacterial exit to the extracellular circumstances. While, remaining half are sorted to autophagosome. The machinery is found to be formed in contact sites between endoplasmic reticulum and mitochondria, which is a very unique finding indicating that 2 different organelle make a concerted effort to the formation of another organelle.
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[Journal Article] Autophagosome forms at the ER-mitochondria contact sites2013
Author(s)
Hamasaki M, Furuta N, Matsuda A, Nezu A, Yamamoto A, Fujita N, Ohmori H, Noda T, Haraguchi T, Hiraoka Y, Amano A, Yoshimori T
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Journal Title
Nature
Volume: 495(7441)
Pages: 389-393
DOI
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[Journal Article] Involvement of a periodontal pathogen, Porphyromonas gingivalis on the pathogenesis of non-alcoholic fatty liver disease2012
Author(s)
Yoneda M, Naka S, Nakano K, Wada K, Endo H, Mawatari H, Imajo K, Nomura R, Hokamura K, Ono M, Murata S, Tohnai I, Sumida Y, Shima T, Kuboniwa M, Umemura K, Kamisaki Y, Amano A, Okanoue T, Ooshima T, Nakajima A
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Journal Title
BMC Gastroenterology
Volume: 12(1)
Pages: 16
DOI
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[Journal Article] Distribution and molecular characterization of Porphyromonas gulae carrying a new fimA genotype2012
Author(s)
Yamasaki Y, Nomura R, Nakano K, Inaba H, Kuboniwa M, Hirai N, Shirai M, Kato Y, Murakami M, Naka S, Iwai S, Matsumoto-Nakano M, Ooshima T, Amano A, Asai F
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Journal Title
Veter inar y Microbiology
Volume: 161 (1)
Pages: 196-205
DOI
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