2014 Fiscal Year Final Research Report
Positive feedback loop of Rac activity on synapse structural plasticity
| Project/Area Number |
24680036
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Partial Multi-year Fund |
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| Research Field |
Neuroscience in general
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
SANEYOSHI Takeo 独立行政法人理化学研究所, 脳科学総合研究センター, 研究員 (00556201)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | シナプス |
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| Outline of Final Research Achievements |
In this grant period, we have successfully visualized Rac activation induced by LTP stimulation by two-photon fluorescent lifetime imaging microscopy (2pFLIM). The Rac 2pFLIM revealed that Rac activation lasted more than 30 min post LTP stimulation, which depended on NMDA-receptor, CaMKII, and TIAM1. We also demonstrated that CaMKII was locked in active conformation through interaction with TIAM1 in independently from phosphorylation of Thr-286.
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| Free Research Field |
神経科学一般
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