Computational biomechanics of interactions between cells and their environment in microcirculation

2014 Fiscal Year Final Research Report

• Project/Area Number: 24680048
• Research Category: Grant-in-Aid for Young Scientists (A)
• Allocation Type: Partial Multi-year Fund
• Research Field: Biomedical engineering/Biological material science
• Research Institution: Tohoku University
• Principal Investigator: IMAI Yohsuke 東北大学, 工学(系)研究科(研究院), 特任准教授 (60431524)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: バイオメカニクス / 計算力学 / 赤血球 / 細胞 / GPU計算

Outline of Final Research Achievements

We developed a graphics processing unit computing method for simulating cellular flows in microcirculation. Fluid mechanics of plasma and cytoplasm is coupled with solid mechanics of membrane, and ligand-receptor bindings for cell adhesion. We quantified the deformation of red blood cells and the rheology of red blood cell suspension. We also analyzed margination, rolling motion and firm adhesion of white blood cells and circulating tumor cells in microcirculatory blood flows.

Free Research Field

計算バイオメカニクス