Label-free imaging technique based on nonlinear optics in biological tissues for medical application

2014 Fiscal Year Final Research Report

• Project/Area Number: 24680060
• Research Category: Grant-in-Aid for Young Scientists (A)
• Allocation Type: Partial Multi-year Fund
• Research Field: Medical systems
• Research Institution: Ehime University
• Principal Investigator: OSHIMA Yusuke 愛媛大学, 医学(系)研究科(研究院), 助教 (10586639)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 無染色イメージング / 第２高調波発生 / ラマン分光 / 非線形光学 / ラマンイメージング / SHGイメージング / 診断

Outline of Final Research Achievements

Optical imaging technique enables us to reveal molecular dynamics and their function in cells and tissues. Especially, Raman spectroscopy and nonlinear optical effect are applicable to label-free imaging of target molecules, therefore it is promising tool for biomedical applications. In this study, we developed high throughput Raman imaging system for clinical diagnostics and successfully evaluated nonlinear microscopy for quantitative analysis of changes in molecular component on animal disease models.

Free Research Field

医用光学