2014 Fiscal Year Final Research Report
Mechanism of androgen production in skeletal muscle and muscle atrophy suppression
| Project/Area Number |
24680070
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Partial Multi-year Fund |
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| Research Field |
Sports science
|
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| Research Institution | Senshu University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
|
| Keywords | アンドロゲン / サルコペニア / 骨格筋 / 自己分泌 |
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| Outline of Final Research Achievements |
It is believed that dihydrotestosterone (DHT) is the most powerful androgen converted by testosterone through 5α-reductase (srd5a1). However, it remains to be elucidated whether muscular DHT production through srd5a1 is locally involved in skeletal muscular plasticity. Here we found that local DHT production in skeletal muscle induced muscular hypertrophy with acceleration of the protein synthesis and inhibited muscular atrophy through the suppression of atrophy-related gene expression. Transcriptional regulation of srd5a1 is controlled by early growth response2 (egr2). These observations indicate that bioactive androgen production through srd5a1 locally play an important role in skeletal muscle metabolism.
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| Free Research Field |
体力科学
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