Rational design and synthesis of lanthanide metal ion complexes for the development of bioimaging probes

2015 Fiscal Year Final Research Report

• Project/Area Number: 24689003
• Research Category: Grant-in-Aid for Young Scientists (A)
• Allocation Type: Partial Multi-year Fund
• Research Field: Physical pharmacy
• Research Institution: The University of Tokyo
• Principal Investigator: HANAOKA KENJIRO 東京大学, 薬学研究科(研究院), 准教授 (70451854)
• Project Period (FY): 2012-04-01 – 2016-03-31
• Keywords: 分析科学 / 分子認識 / 薬学 / 有機化学 / イメージング / MRI / 蛍光 / 低酸素

Outline of Final Research Achievements

In this study, we tried to utilize the unique chemical properties of lanthanide metal ions for the rational development of imaging probes in different modalities: (1) MRI probes and (2) fluorescent probes, aimed for the application in life sciences. So far, we have successfully developed a MRI probe for hypoxia, which showed MRI signal increase in response to hypoxia, a MRI probe accumulating at the site of atherosclerosis, several fluorescent probes, and so on. Unusual hypoxia inside bodies is related to various diseases including tumors, and also early detection of atherosclerosis is extremely important for the treatment.

Free Research Field

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