Function of Flower system in the regulation of hematopoietic stem cell

2014 Fiscal Year Final Research Report

• Project/Area Number: 24689041
• Research Category: Grant-in-Aid for Young Scientists (A)
• Allocation Type: Partial Multi-year Fund
• Research Field: Hematology
• Research Institution: Kyushu University (2014); Keio University (2012-2013)
• Principal Investigator: HOSOKAWA Kentaro 九州大学, 医学(系)研究科(研究院), 助教 (90569584)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 細胞競合 / 造血幹細胞 / 増殖制御 / Flower / Hippo

Outline of Final Research Achievements

The purpose of this research was the elucidation of the proliferation and self-renewal control mechanism of the hematopoietic stem cells (HSCs) by the cell competition through Flower code or Hippo pathway in the bone marrow niche. For this purpose, we analyzed the effect of these pathways on the regulation of HSCs proliferation at the cell competition. We found that Flower isoform Fwe1 showed proliferative advantage (winner) and Fwe2 indicated recessive (loser). It was suggested that Flower was the indicator to eliminate HSCs of low fitness for the maintenance of tissue homeostasis.
On the other hand, we found that Lats1/2 regulated HSCs proliferation in the cell competition by analyzing of Lats KO HSCs. It was suggested that Hippo signal was also involved in cell competition system of HSCs.

Free Research Field

幹細胞生物学