2013 Fiscal Year Final Research Report
The feedback signaling from neurons to neural stem cells
| Project/Area Number |
24700361
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Nerve anatomy/Neuropathology
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| Research Institution | Institute of Physical and Chemical Research |
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Principal Investigator |
SHITAMUKAI Atsunori 独立行政法人理化学研究所, 発生・再生科学総合研究センター, 専門職研究員 (00442971)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | 神経幹細胞 / 神経 / 自己複製 / 神経層形成 |
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| Research Abstract |
The radial glial (RG) cells are multipotent stem cells in the developing brain. During this stage, the different types of neurons are produced sequentially in a stage-dependent manner and the final six-layered structure is formed. The mechanism of the RG cell maintenance has been well studied; however, it is largely unknown how the population of distinct progeny is controlled. We found that a neuronal FGF, FGF18 is important for this process. The FGF18 gene is expressed in the neural layer at the middle stage of neurogenesis, but not at the early stage. The brain of FGF18 KO mice showed a reduction in RG cell numbers at the middle stage of neurogenesis and a specific reduction of late born neuron numbers at the postnatal stage. From these results, we propose a feedback signaling from neurons to radial glia cells, in which the early born neurons control the number of late born neurons that are generated.
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[Journal Article] Amplification of progenitors in the mammalian telencephalon includes a new radial glial cell type2013
Author(s)
Gregor-Alexander Pilz, Atsunori Shitamukai, Isabel Reillo, Emilie Pacary, Julia Schwausch, Ronny Stahl, Jovica Ninkovic, Hugo J Snippert, Hans Clevers, Leanne Godinho, Francois Guillemot, Victor Borrell, Fumio Matsuzaki, Magdalena Gotz.
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Journal Title
Nature Communications
Volume: 4
DOI
Peer Reviewed
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[Journal Article] Evidence of Antagonistic Regulation of Restart from G1 Delay in Response to Osmotic Stress by the Hog1 and Whi3 in Budding Yeast2013
Author(s)
Masaki Mizunuma, Takafumi Ogawa, Tetsuya Koyama, Atsunori Shitamukai, Ryohei Tsubakiyama, Tadamasa Komaruyama, Toshinaga Yamaguchi, Kazunori Kume, Dai Hirata
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Journal Title
Bioscience, biotechnology, and biochemistry
Volume: 77
Pages: 2002-2007
DOI
Peer Reviewed
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[Journal Article] Improving spinning disk confocal microscopy by preventing pinhole cross-talk for intravital imaging2013
Author(s)
Togo Shimozawa, Kazuo Yamagata, Takefumi Kondo, Shigeo Hayashi, Atsunori Shitamukai, Daijiro Konno, Fumio Matsuzaki, Jun Takayama, Shuichi Onami, Hiroshi Nakayama, Yasuhito Kosugi, Tomonobu M. Watanabe, Katsumasa Fujita, Yuko Mimori-Kiyosue
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Journal Title
Proc. Natl. Acad. Sci. U. S. A.
Volume: 110
Pages: 3399-3404
DOI
Peer Reviewed
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