2013 Fiscal Year Final Research Report
Mechanism of aggregation-independent neurotoxicity induced by tau
| Project/Area Number |
24700368
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Nerve anatomy/Neuropathology
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| Research Institution | Doshisha University |
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Principal Investigator |
XIE Ce 同志社大学, 生命医科学部, 特別研究員 (10598981)
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| Project Period (FY) |
2012 – 2013
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| Keywords | タウ / タウオパチー / 認知症 / 線虫 |
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| Research Abstract |
Microtubule-associated protein tau aggregates and deposits in the degenerated neurons of many dementia developed with aging. These diseases are called tauopathies, which mechanism is still unclear. The proteins that associated with the abnormal tau are considered to be deeply related to the neurotoxic mechanism. In this study, we identified the proteins that may be involved in the toxic mechanism of tau, using a C. elegans model, in which abnormal tau was expressed without aggregation formation.
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