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2013 Fiscal Year Final Research Report

Regulated processing of neuregulin1 precursors in rat cortical neurons

Research Project

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Project/Area Number 24700375
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Neurochemistry/Neuropharmacology
Research InstitutionNiigata University

Principal Investigator

IWAKURA Yuriko  新潟大学, 脳研究所, 助教 (40452081)

Project Period (FY) 2012-04-01 – 2014-03-31
Keywords神経細胞 / ニューレグリン1 / グルタミン酸受容体 / メタロプロテアーゼ / 大脳皮質
Research Abstract

Neuregulin1 (NRG1) belongs to the family of epidermal growth factor (EGF) and is implicated in synaptic plasticity of glutamatergic transmission and neuronal and glial development. Recent genetic studies also indicate the association of this gene with a schizophrenia risk. However, the regulation of NRG1 processing and release in brain is poorly understood. Here we examined glutamate neurotransmission has a regulatory role in NRG1 processing and release in the central nervous system.

  • Research Products

    (3 results)

All 2014 2013 2012

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (2 results)

  • [Journal Article] ErbB1-4-dependent EGF/neuregulin signals and their cross talk in the central nervous system : pathological implications in schizophrenia and Parkinson's disease (review)2013

    • Author(s)
      Iwakura Y. and Nawa H.
    • Journal Title

      Frontiers in Cellular Neuroscience

      Volume: 7(4)

    • DOI

      10.3389/fncel.2013.00004.Epub2013Feb13

    • Peer Reviewed
  • [Presentation] 細胞外ドメインのシェディングを介した、EGFファミリーと神経伝達物質のクロストーク2014

    • Author(s)
      岩倉百合子
    • Organizer
      新潟脳研―生理研合同シンポジウム
    • Place of Presentation
      愛知県岡崎市
    • Year and Date
      2014-02-26
  • [Presentation] Regulated processing of neuregulin-1 precursors in rat cortical neurons2012

    • Author(s)
      Iwakura Y, Wang R, Araki K, Tanemura S, Nawa H.
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      福岡県福岡市
    • Year and Date
      2012-12-13

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Published: 2015-06-25  

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