Selective transduction into parallel fiber or climbing fiber using antibody-displaying viral vector

2014 Fiscal Year Final Research Report

• Project/Area Number: 24700394
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Neurophysiology and muscle physiology
• Research Institution: Gunma University
• Principal Investigator: KONNO Ayumu 群馬大学, 医学(系)研究科(研究院), 助教 (40509048)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: ウイルスベクター / 小脳

Outline of Final Research Achievements

The aim of this research is to establish the method for a selective transduction into parallel fiber or climbing fiber in a mouse cerebellum using an antibody-displaying viral vector. To achieve this aim, we made new antibodies against lumenal domain of VGluT1 or VGluT2. We injected the lentiviral vectors displaying these antibodies into mice cerebellum. However, these vectors could not infect specific cells that were expected. To achieve this aim, we need a different approaches such as adeno-associated virus vector.

Free Research Field

神経科学