Analysis of molecular processes between cells and artificial materials by surface-enhanced Raman spectroscopy

2014 Fiscal Year Final Research Report

• Project/Area Number: 24700449
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Biomedical engineering/Biological material science
• Research Institution: Tokyo Institute of Technology
• Principal Investigator: HAYASHI Tomohiro 東京工業大学, 総合理工学研究科(研究院), 准教授 (30401574)
• Co-Investigator(Renkei-kenkyūsha): TANAKA Masaru 九州大学, 大学院先導物質化学研究所, 教授 (00322850) ; AKAIKE Toshihiro 東京工業大学, 大学院生命理工学研究科, 教授 (30101207)
• Research Collaborator: GRUNZE Michael University of Heidelberg, Angewandte Physikalische Chemie, Professor
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: バイオインターフェース / ナノバイオ / 表面分光

Outline of Final Research Achievements

The aim of this work is to investigate molecular processes occurring between living cells and artificial materials by surface-enhanced Raman scattering. Through this project, we develop the optical system and metallic substrates for surface-enhanced Raman scattering. We succeeded in acquiring the Raman spectra of extra-cellular matrix.
In addition, we developed a method to identify proteins constituting extra-cellular matrix by using MALDI ToF Mass spectroscopy. In this method, all processes can be done on the substrate, different from the conventional sample preparations.

Free Research Field

表面科学