Analysis of decellularized small diameter blood vessel that has anti-thrombus and its application to small diameter artificial blood vessel

2014 Fiscal Year Final Research Report

• Project/Area Number: 24700458
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Biomedical engineering/Biological material science
• Research Institution: Tokyo Medical and Dental University (2014); Sapporo Medical University (2012-2013)
• Principal Investigator: FUNAMOTO SEIICHI 東京医科歯科大学, 生体材料工学研究所, 准教授 (40609947)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: バイオマテリアル / 循環器 / 脱細胞化組織

Outline of Final Research Achievements

Intravascular lumen is composed of basement membrane called tissue and endothelial cells. Vascular endothelial cells have the function of anti-thrombotic. Early Vascular -endothelialization due to maintenance of basement membrane structure of decellularized blood vessel is important for the maintenance of blood flow of small-diameter vascular graft. In this project was to evaluate the decellularized vascular lumen structure. Also explored the relationship of the basement membrane structure and endothelial cell function performs a vascular endothelial cell seeding to the decellularized vascular lumen. As the results, tissue regeneration by cell infiltration after transplantation has been observed. Decellularized small-diameter artery was not recognized early thrombus formation and constriction.

Free Research Field

組織工学