Investigating mechanisms of ventricular arrhythmias induced in the Purkinje fiber network using computer simulation

2014 Fiscal Year Final Research Report

• Project/Area Number: 24700470
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Biomedical engineering/Biological material science
• Research Institution: National Cardiovascular Center Research Institute
• Principal Investigator: HARAGUCHI Ryo 独立行政法人国立循環器病研究センター, 情報統括部, 室長 (00393215)
• Research Collaborator: ASHIHARA Takashi 滋賀医科大学, 医学部, 助教(学内講師) (80396259) ; TSUMOTO Kunichika 大阪大学, 医学研究科, 助教 (70353331) ; YAMAGUCHI Takeshi 四国大学, 看護学 (60532182) ; NAKAZAWA Kazuo 国立循環器病研究センター, 研究所, 室長 (50198058) ; INADA Shin 国立循環器病研究センター, 研究所, 特任研究員 (50349792) ; HARRELL Daniel T. 長崎大学
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 不整脈 / シミュレーション / 生体システム・フィジオーム

Outline of Final Research Achievements

Cardiac conduction system plays an important role in heart as a blood pump. Purkinje fiber network that run throughout the ventricles inside may be responsible for various arrhythmias. Our computer simulation results suggest that both morphological characters and electrical conductivity of Purkinje fiber network are important factor for arrhythmia occurrence of Purkinje origin. We performed computer simulations with 3-D model involved in electrophysiological model of a human purkinje/ventricular cell. Furthermore, we performed the 3D reconstruction of cardiac conduction system based on serial histological specimens. These technologies will lead to the construction of a simulation model which is electrophysiologically and morphologically reasonable.

Free Research Field

生体医工学