Genetic variants and ectopic lipid alterations during aerobic exercise and calorie restriction

2014 Fiscal Year Final Research Report

• Project/Area Number: 24700769
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Applied health science
• Research Institution: University of Nagasaki
• Principal Investigator: TOBINA Takuro 長崎県立大学, 看護栄養学部, 講師 (60509678)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 遺伝子多型 / 生活習慣病 / メタボリックシンドローム / 骨格筋 / ミトコンドリア

Outline of Final Research Achievements

This study investigated the association with genetic variants that plays as nuclear transcriptional factor and ectopic lipids during aerobic exercise and diet induced calorie restriction. Before interventions, Ser allele of PGC-1 gene Gly482Ser polymorphism and C allele of PPARδ T294C influences hepatic and muscular lipid accumulation. After exercise training and diet intervention, the changes of those lipids contents were no differences among the genotypes. However, Gly allele and T allele associates more improvement glucose metabolism and LDL-cholesterol in exercise training group. In diet group, those gene polymorphisms also influenced the changes of muscular mitochondrial contents, and fasting glucose level. This study suggested that the genetic variants of PGC-1 Gly482Ser and PPARδT294C may affects exercise and diet induced glucose and lipid energy metabolism.

Free Research Field

運動生理学