2013 Fiscal Year Final Research Report
Strategy for gout prevention based on pharmacodynamics and pharmacokinetics of antioxidants
| Project/Area Number |
24700819
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Eating habits, studies on eating habits
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| Research Institution | Hokkaido University |
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Principal Investigator |
OGURA Jiro 北海道大学, 薬学研究科(研究院), 助教 (20580640)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | 痛風 / BCRP / 抗酸化物質 / 薬力学的特性 / 薬物動態学的特性 |
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| Research Abstract |
The purpose of this study is development of gout prevention targeting BCRP, which is a urate efflux transporter. We found that caffeic acid is effective in scavenging reactive oxygen species (ROS) derived from xanthine oxidase and NADPH oxidase. ROS derived from these oxidases can suppress BCRP S-S bond formation. Moreover, we found that accumulation of caffeic acid in intestinal epithelial cells was important for ROS scavenging activity of caffeic acid.
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