2013 Fiscal Year Final Research Report
Molecular mechanism of transcriptional regulation by NFATc in tumor endothelial cells
| Project/Area Number |
24700969
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Tumor biology
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| Research Institution | Kyorin University (2013)
The University of Tokyo (2012) |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | 血管内皮細胞 / 腫瘍血管新生 / ＶＥＧＦ / ＮＦＡＴｃ |
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| Research Abstract |
To elucidate molecular mechanism of transcriptional activation by NFATc, I performed global analysis of target genes using microarray and ChIP-seq and examined beta-galactosidase activities in hprt locus-target in EGR3 promoter-lacZ transgenic mice. CXCR7 and RND1 were first identified as NFATc targets and contributed to VEGF-mediated angiogenesis. NFAT-mediated EGR3 promoter activities in vivo were upregulated by inflammatory stimuli in various types of endothelial cells.
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[Journal Article] Inhibition of histone demethylase JMJD1A improves anti-angiogenic therapy and reduces tumor associated macrophages2013
Author(s)
Osawa T, Tsuchida R, Muramatsu M, Shimamura T, Wang F, Suehiro J, Kanki Y, Wada Y, Yuasa Y, Aburatani H, Miyano S, Minami T, Kodama T, and Shibuya M
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Journal Title
Cancer Research
Volume: 73(10)
Pages: 3019-28
DOI
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[Journal Article] Dynamic change of the chromatin conformation in response to hypoxia enhances the expression of GLUT3 (SLC2A3) by cooperative interaction of HIF1 and KDM3A2012
Author(s)
Mimura I, Nangaku M, Kanki Y, Tsutsumi S, Inoue T, Kohro T, Yamamoto S, Fujita T, Shimamura T, Suehiro JI, Taguchi A, Kobayashi M, Tanimura K, Inagaki T, Tanaka T, Hamakubo T, Sakai J, Aburatani H, Kodama T, Wada Y
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Journal Title
Mol Cell Biol
Volume: 32(15)
Pages: 3018-32
DOI
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