Study of molecular pathogenesis of myelodysplastic syndromes based on transcriptome analysis

2013 Fiscal Year Final Research Report

• Project/Area Number: 24700970
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Tumor biology
• Research Institution: The University of Tokyo
• Principal Investigator: SATO Aiko 東京大学, 医学部附属病院, 特任研究員 (70512573)
• Project Period (FY): 2012 – 2013
• Keywords: トランスクリプトーム / スプライシング

Research Abstract

Frequent pathway mutation of RNA splicing machinery was reported recently. We comprehensively analyzed the aberrant RNA caused by the mutation using transcriptome analysis with next generation sequencing. Abnormally spliced transcripts were globally identified by the experiment of cell lines in which mutant genes were expressed. The wide-ranging abnormality of RNA was observed in each mutant. Further analysis of multiple MDS specimens will reveal the specific genes and pathways that explain the molecular pathogenesis of MDS.