2014 Fiscal Year Final Research Report
Discover of genes associated with malignant potential of cancer cells
Project/Area Number |
24701004
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Tumor diagnosis
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Research Institution | University of Toyama |
Principal Investigator |
ANDO Takayuki 富山大学, 大学院医学薬学研究部(医学), 助教 (30600671)
|
Project Period (FY) |
2012-04-01 – 2015-03-31
|
Keywords | DNAメチル化 / 突然変異 / 神経内分泌癌 / 腺癌 |
Outline of Final Research Achievements |
Comprehensive methylation analysis of 20 gastric cancers revealed that the number of aberrantly methylated genes was highly variable between individual gastric NEC and adenocarcinoma. Among 715 genes of tumor-specific methylations discovered, 13 genes with promoter methylation in >30% of NECs and 0% of adenocarcinomas were identified. Some of these genes are known to regulate cell differentiation and cell cycle, and DNA methylation-silencing are suggested to be involved in carcinogenesis of gastric NECs.
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Free Research Field |
DNAメチル化
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