2013 Fiscal Year Final Research Report
Development of glycan immobilization technique for virus detection and its device applications
| Project/Area Number |
24710136
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Nanomaterials/Nanobioscience
|
|---|
| Research Institution | Waseda University |
|---|
Principal Investigator |
HIDESHIMA SHO 早稲田大学, ナノ理工学研究機構, 講師 (10580433)
|
|---|
| Project Period (FY) |
2012-04-01 – 2014-03-31
|
| Keywords | ナノバイオ / 糖鎖 / バイオセンシング / 電界効果トランジスタバイオセンサ / インフルエンザウイルス |
|---|
| Research Abstract |
I have developed a glycan immobilization technique for biosensing devices based on filed effect transistors towards influenza virus detection. Highly dense and oriented glycan immobilization has been achieved by introducing an aminooxy-terminated self-assembled monolayer on the sensing surface. The glycan-immobilized FET could detect influenza virus hemagglutinin at attomolar-level sensitivity. The results suggest that the glycan-immobilized FETs developed in the project have potential to detect influenza virus with the high sensitivity.
|
