2015 Fiscal Year Final Research Report
DEVELOPING NOVEL VACCINE ADJUVANTS BASED ON BETA-GLUCAN
| Project/Area Number |
24710242
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Living organism molecular science
|
|---|
| Research Institution | Hokkaido University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2012-04-01 – 2016-03-31
|
| Keywords | Glucan / biopolymers / conjugation / chemical synthesis / binding assays |
|---|
| Outline of Final Research Achievements |
The final aim of the project is to develop novel glycan-derivatives with application on immunotherapy.
During this term, the main investigator was able to follow the project based on beta-glucan conjugates. First, we focus on the developing of novel conjugates based on 1,3-beta-glucans. Immune system is able to recognize long glucans forming a triple helix structure; the aim is to mimic the same structure by using shorter polymers of beta-glucans conjugated with peptides. After challenging several drawbacks, the glycoconjugates were finally synthesized, finally structural and biological assays are undergoing.
This is a very challenging project including chemical synthesis on solid-phase, solution and biological evaluation, we got successful results and further studies are still undergoing. We are very confident to get a potential candidate as an immune system modulator. Further, this findings and novel approaches open avenues for broader applications.
|
| Free Research Field |
Chemical biology
|
