2014 Fiscal Year Final Research Report
Design and Synthesis of Bioactive Sugar Chain Mimics
| Project/Area Number |
24710248
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Living organism molecular science
|
|---|
| Research Institution | Tokyo Institute of Technology |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2012-04-01 – 2015-03-31
|
| Keywords | 糖鎖ミミック / 糖鎖 / シアル酸 / 複合糖質 |
|---|
| Outline of Final Research Achievements |
Synthesis of the desirable sugar chains is very cumbersome process due to very diverse and complex structures of natural sugar chains. In this study, we attempted to construct the sugar chain mimics having a similar biofunction to natural sugar chians by following strategies. (1) To mimic the chain-like structure, we replace the interior sugar unit to the appropriate diol and synthesized sialic acid terminated trisaccharide mimic framework.(2) To mimic the glyco cluster, we constructed the sugar units multimer by introduction of the synthesized sugar units to the carrier (nanoparticle or multi functionalized small molecule).
|
| Free Research Field |
天然物化学、糖化学、有機合成化学
|
