Geographical distribution and triazole resistant of the human pathogenic fungi Aspergillus fumigatus and related species in Japan

2014 Fiscal Year Final Research Report

• Project/Area Number: 24710277
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Resource conservation science
• Research Institution: Nihon University
• Principal Investigator: HIROSE Dai 日本大学, 薬学部, 助教 (20513922)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: アスペルギルス症 / 環境 / 遺伝的変異 / 集団遺伝 / アゾール / 地理的分布

Outline of Final Research Achievements

Aspergillus fumigatus is one of the most important fungal pathogens of humans. Geographical distribution and triazole resistant of A. fumigatus and related species have been studied in Japan. The distribution of A. fumigatus depended on soil environments and latitude. There was no azole-resistant isolate of A. fumigatus from natural environments. The results of population genetical analysis suggested that Japanese A. fumigatus genotypes are genetically differentiated into two populations not correlated with geographical distance. Aspergillus fumigatus related species were broadly distributed in Japan, though the abundances of these species were much lower than one of A. fumigatus. The frequencies of azole resistance of A. fumigatus related species from natural environments were much high.

Free Research Field

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