2014 Fiscal Year Final Research Report
Development of Coupling Reactions between Enol Ethers with Metal Enolates via Characteristic Lewis Acids
| Project/Area Number |
24750090
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Synthetic chemistry
|
|---|
| Research Institution | Osaka University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2012-04-01 – 2015-03-31
|
| Keywords | 有機合成化学 / 有機金属化学 |
|---|
| Outline of Final Research Achievements |
The coupling reaction between enol ethers and silyl ketene acetals in the presence of gallium tribromide catalyst. In this reaction system, various types of enol ethers and silyl ketene acetals were applicable. As far as enol ethers, not only vinyl ethers but also substituted alkenyl ethers were found to be suitable substrates. The scope of silyl ketene acetals was also wide so that diallkyl-, diaryl-, and alkylarylsubstituted ones afforded the corresponding products in high yields. The observation of the reaction intermediate and kinetic study revealed that the coupling reaction proceeds via carbogallation among gallium tribromide, an enol ether, and a silyl ketene acetal.
|
| Free Research Field |
有機化学
|
