2014 Fiscal Year Final Research Report
Analysis and functional elucidation of glycolipids in neural stem cell under cerebral hypothermia condition
| Project/Area Number |
24750164
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Chemistry related to living body
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| Research Institution | Nihon University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 神経幹細胞 / 糖脂質 / 糖タンパク質 / 脳低温療法 |
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| Outline of Final Research Achievements |
Cerebral hypothermia has been evaluated and used for clinical application of hypoxic-ischemic encephalopathy, cerebral edema, and cerebral infarction due to inflammation after brain injury. Recently, apoptosis induced by depletion of epidermal growth factor (EGF) in neural stem cell line (MEB5) has also reported to be suppressed under similar culture condition to cerebral hypothermia. However, the regulation mechanism of apoptosis in MEB5 under hypothermia condition is still unknown. In this study, we analyzed glycolipid composition and glycoproteins in MEB5 after culture under cerebral hypothermia condition and found that these glycoconjugates would be related to the regulation mechanism of apoptosis.
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| Free Research Field |
神経化学，分子生物学，糖質化学
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