2013 Fiscal Year Final Research Report
Estimation of Biocompatibility of Polymeric Materials without Living Cells
| Project/Area Number |
24750216
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Polymer/Textile materials
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| Research Institution | University of Toyama |
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Principal Investigator |
GEMMEI Makoto 富山大学, 大学院理工学研究部(工学), 准教授 (70334711)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | 高分子機能材料 / 生体適合性 / 表面の水 |
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| Research Abstract |
Attenuated total reflectance (ATR) near infrared (NIR) and middle infrared (MIR) spectroscopes, which have the ability to observe the water-solid interface selectively, were constructed. Using ATR-NIR, a combination band (7000 cm-1) of OH symmetric and asymmetric stretching of water on hydrophilic (silanol) and hydrophobic (alkylated) solid surfaces was obtained. The ATR-NIR spectra indicated that the density of water on both the hydrophilic and hydrophobic surfaces increased in the range of 100 nm from the surface. Using ATR-MIR, amide I (1650 cm-1) and amide II (1550 cm-1) bands of the protein adsorbed on the surface were obtained. Structural change of the adsorbed protein on the hydrophobic surface was faster than that on the hydrophilic surface. A good correlation between the water structures and the structural changes of an adsorbed protein on the hydrophilic / hydrophobic surfaces was not observed.
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