2013 Fiscal Year Final Research Report
Preparation of novel iontophoresis electrodes by an electrolytic deposition method
Project/Area Number |
24760570
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Multi-year Fund |
Research Field |
Structural/Functional materials
|
Research Institution | Tokyo Institute of Technology |
Principal Investigator |
|
Project Period (FY) |
2012-04-01 – 2014-03-31
|
Keywords | イオントフォレシス / 経皮吸収 / DDS |
Research Abstract |
This study is concerned with the preparation of novel iontophoresis electrodes delivering drugs through the skin into the body. The electrodes were prepared by electrochemical deposition of alginic acid gels on aluminum substrates. The deposited gels were tightly bonded on the substrates through the interaction between alginic acid and surface oxides of the substrates. The electrodes prepared loaded lidocaine electrostatically, and released the drug by applying external electric fields. Equivalent circuits for the electrode/rat skin system were analyzed, so that the use of AC iontophoresis is thought to be effective for transdermal drug delivery with the electrode prepared.
|
Research Products
(6 results)
-
-
[Presentation] AC Iontophoresis of Lidocaine with Alginic-Acid Gel Electrodes2013
Author(s)
Tomoko Ebisawa, Katsuhiro Matsumoto, Atsuhi Nakajima, Haruka Haida, Shizuka Ando, Tomohiko Yoshioka, Toshiyuki Ikoma, Junzo Tanaka, and Haruhisa Fukayama
Organizer
The 4^<th> International Symposium on Advanced Materials Development and Integration of Novel Structured Metallic and Inorganic Materials (AMDI-4)
Place of Presentation
Nagoya University (Nagoya, Japan)
Year and Date
2013-12-14
-
-
[Presentation] Electrochemically deposited gels for transdermal drug delivery2012
Author(s)
Tomohiko Yoshioka, Norio Saito, Toshiyuki Ikoma, Naoki Ohashi, Haruka Haida, Atsushi Nakajima, Ryo Wakita, Haruhisa Fukayama, Masahiro Umino, and Junzo Tanaka
Organizer
9^<th> World Biomaterials Congress
Place of Presentation
Century City International Convention Center (Chengdu, China)
Year and Date
20120604-05
-
[Presentation] Electro-responsive drug delivery of electrochemically deposited alginic acid gels on metals2012
Author(s)
Tomohiko Yoshioka, Norio Saito, Toshiyuki Ikoma, Naoki Ohashi, Tomoko Ebisawa, Haruka Haida, Atsuhi Nakajima, Ryo Wakita, Haruhisa Fukayama, Masahiro Umino, and Junzo Tanaka
Organizer
The 3^<rd> International Symposium on Advanced Materials Development and Integration of Novel Structured Metallic and Inorganic Materials (AMDI-3)
Place of Presentation
Hotel Nikko Toyohashi (Aichi, Japan)
Year and Date
2012-11-05
-