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2013 Fiscal Year Final Research Report

Analysis of body axis formation of mouse postimplantation development

Research Project

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Project/Area Number 24770219
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Developmental biology
Research InstitutionInstitute of Physical and Chemical Research

Principal Investigator

SHIOI Go  独立行政法人理化学研究所, 発生・再生科学総合研究センター, 専門職研究員 (60391968)

Project Period (FY) 2012-04-01 – 2014-03-31
Keywords前後軸形成 / 胚培養 / ライブイメージング / レポーターマウス / 細胞挙動
Research Abstract

To reveal the mechanism of the anterior-posterior (A-P) axis formation in a mouse embryo, the expression pattern of head organizer genes have been reexamined. I found that OTX2 gene was asymmetrically expressed from the very beginning of their expression. The gene which makes Otx2 express asymmetrically might have an important role to develop A-P axis. I also established a culture system of mouse embryos for live-imaging experiments. Then, the behavior of each embryonic visceral endoderm cell during the A-P axis formation has been examined by live-imaging experiments. I found some characteristic cell behaviors which remained to be reported.

  • Research Products

    (8 results)

All 2014 2013

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (7 results)

  • [Journal Article] Visualization of cell cycle in mouse embryos with Fucci2 reporter directed by Rosa26 promoter2013

    • Author(s)
      Abe T, Sakaue-Sawano A, Kiyonari H, Shioi G, Inoue K, Horiuchi T, Nakao K, Miyawaki A, Aizawa S, Fujimori T.
    • Journal Title

      Development

      Volume: 140(1) Pages: 237-46

    • DOI

      10.1242/dev.084111

    • Peer Reviewed
  • [Presentation] Live Imaging Analysis of Mouse Development during AVE Formation2014

    • Author(s)
      Go Shioi, Hideharu Hoshino, Kana Bando, Kazuki Nakao, Toshihiko Fujimori and Shinichi Aizawa
    • Organizer
      47^<th> Annual meeting of the Japanese society of developmental biologists
    • Place of Presentation
      Nagoya, Japan
    • Year and Date
      20140527-30
  • [Presentation] Live Imaging Analysis of Mouse Postimplantation Development2013

    • Author(s)
      Go Shioi, Hideharu Hoshino, Kana Bando, Kazuki Nakao, Toshihiko Fujimori and Shinichi Aizawa
    • Organizer
      The 36^<th> Annual meeting of the molecular biology society of japan
    • Place of Presentation
      Kobe, Japan
    • Year and Date
      20131203-06
  • [Presentation] Live Imaging Analysis of Mouse Postimplantation Development2013

    • Author(s)
      Go Shioi, Hideharu Hoshino, Kana Bando, Kazuki Nakao, Toshihiko Fujimori and Shinichi Aizawa
    • Organizer
      The 61st NIBB Conference : Cellular Community in Mammalian Embryogenesis
    • Place of Presentation
      Okazaki, Japan
    • Year and Date
      20130710-12
  • [Presentation] Live Imaging Analysis of Mouse Postimplantation Development2013

    • Author(s)
      Go Shioi, Hideharu Hoshino, Kana Bando, Kazuki Nakao, Toshihiko Fujimori and Shinichi Aizawa
    • Organizer
      46^<th> Annual meeting of the Japanese society of developmental biologists
    • Place of Presentation
      Matsue, Japan
    • Year and Date
      20130529-31
  • [Presentation] OTX2 and DKK1 Exhibit the Earliest Asymmetric Expression in Distal Visceral Endoderm2013

    • Author(s)
      Hoshino Hideharu, Go Shioi, Takaya Abe, Kazuki Nakao, Shinichi Aizawa
    • Organizer
      46^<th> Annual meeting of the Japanese society of developmental biologists
    • Place of Presentation
      Matsue, Japan
    • Year and Date
      20130529-31
  • [Presentation] Live Imaging Analysis of Mouse Postimplantation Development2013

    • Author(s)
      Go Shioi, Hideharu Hoshino, Kana Bando, Kazuki Nakao, Toshihiko Fujimori and Shinichi Aizawa
    • Organizer
      CDB Symposium 2013 : The making of a vertebrate
    • Place of Presentation
      Kobe Japan
    • Year and Date
      20130304-06
  • [Presentation] OTX2 and DKK1 Exhibit the Earliest Asymmetric Expression in Distal Visceral Endoderm2013

    • Author(s)
      Hoshino Hideharu, Go Shioi, Takaya Abe, Kazuki Nakao, Shinichi Aizawa
    • Organizer
      CDB Symposium 2013 : The making of a vertebrate
    • Place of Presentation
      Kobe Japan
    • Year and Date
      20130304-06

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Published: 2015-06-25  

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