2013 Fiscal Year Final Research Report
Behavioral analysis of function of amylin in the brain center of the parental behavior
| Project/Area Number |
24780292
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Basic veterinary science/Basic zootechnical science
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| Research Institution | Toho University (2013)
The Institute of Physical and Chemical Research (2012) |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | アミリン / 内側視索前野 / 養育行動 |
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| Research Abstract |
Parental behavior is essential for mammalian reproduction, and its plasticity depending on the social experiences has been known. Understanding such mechanisms on the plasticity of parental behavior should contribute the effective reproduction of domestic animals and solve the offsprings' mental problems caused by poor parental care. Amylin is known as feeding control polypeptide, expressed in the brain center of the parental behavior, the medial preoptic area. In this study, we showed the dynamics of amylin expression related to the reproductive cycle and the cohabitation with others. ICV injection of amylin reduced feeding and aggressive behavior of mice, while the amylin treatment did not altered the parental behavior of mice.
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