2013 Fiscal Year Final Research Report
Role of 2'-5'-oligoadenylate synthetases in the pathogenicity of flavivirus encephalitis
| Project/Area Number |
24780293
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Applied veterinary science
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| Research Institution | Hokkaido University |
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Principal Investigator |
YOSHII KENTARO 北海道大学, (連合)獣医学研究科, 准教授 (50421988)
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| Co-Investigator(Renkei-kenkyūsha) |
KARIWA Hiroaki 北海道大学, 大学院獣医学研究科, 教授 (70224714)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | フラビウイルス / 脳炎 / ＯＡＳ / 人獣共通感染症 |
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| Research Abstract |
Flaviviruses include many clinically important zoonotic pathogens, and some of them cause severe encephalitis in humans and domestic animals. In study, we showed that congenic mice expressing intact Oas1b can be applied for detailed analysis of pathogenicity of flavivirus encephalitis. Furthermore, we revealed that mutations which arose during adaptation in mammals increased the virulence of tick-borne flaviviruses.
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[Journal Article] Development of a diagnostic method applicable to various serotypes of hantavirus infection in rodents2012
Author(s)
Sanada T, Kariwa H, Saasa N, Yoshikawa K, Seto T, Morozov VG, Tkachenko EA, Ivanov LI, Yoshimatsu K, Arikawa J, Yoshii K, Takashima I
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Journal Title
J Vet Med Sci
Volume: 74
Pages: 1237-1242
Peer Reviewed
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[Presentation] Characterization of Hokkaido virus, genus hantavirus2012
Author(s)
Sanada, T., Ozaki, Y., Seto, T., Nakao, M., Saasa, N., Yoshimatsu, K., Arikawa, J., Yoshii, K., and Kariwa, H.
Organizer
The 4th International Young Researcher Seminar for Zoonosis Control
Place of Presentation
Sapporo
Year and Date
2012-09-20
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[Presentation] Critical Determinant of Neurologic Disease of Tick-borne Flaviviruses2012
Author(s)
Yoshii, K., Sunden, Y., Yokozawa, K., Kariwa, H., Holbrook, M.R., and Takashima, I.
Organizer
46th Joint Working Conference on Viral Diseases, The Japan-United States Cooperative Medical Science Program
Place of Presentation
Beppu
Year and Date
2012-06-20
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