2013 Fiscal Year Final Research Report
The study of therapy for canine pituitary adenomas by 11beta-HSD inhibitor
| Project/Area Number |
24780315
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Clinical veterinary science
|
|---|
| Research Institution | Nippon Veterinary and Life Science University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2012-04-01 – 2014-03-31
|
| Keywords | 下垂体 / ACTH / クッシング症候群 / 11β-HSD |
|---|
| Research Abstract |
It was revealed that the effect of 11beta-HSD inhibitor on dogs was dose-dependent in this study. From the result of our study, it was suggested that ACTH secretion from pituitary was decreased by 11beta-HSD inhibitor in healthy dogs. Moreover, apparent side effects were not observed in the long term administration period of 11beta-HSD inhibitor. We have to research the effect of 11beta-HSD inhibitor on dogs with canine pituitary ACTH adenomas.
In conclusion, we expect that there is possibility that 11beta-HSD inhibitor can be therapeutic drug for canine pituitary ACTH adenoma. Furthermore, we need to proceed this study for treatment of caine pituitary ACTH adenomas.
|
