2013 Fiscal Year Final Research Report
Induction of antitumor immunity by nanoparticle incorporating alpha-galactocylceramide
| Project/Area Number |
24790037
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Physical pharmacy
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| Research Institution | Hokkaido University |
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Principal Investigator |
NAKAMURA Takashi 北海道大学, 薬学研究科(研究院), 助教 (20604458)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | ドラッグデリバリー / リポソーム / ワクチン / 癌免疫療法 / 脂質抗原 |
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| Research Abstract |
Alpha-galactosylceramide (GC), a lipid antigen present on CD1d molecules, is predicted to have clinical applications as a new class of adjuvant, because GC strongly activates natural killer T (NKT) cells which produce large amounts of IFN-gamma. Here, we incorporated GC into stearylated octaarginine-modified liposomes (R8-Lip), our original delivery system developed for vaccines, and investigated the effect of nanoparticulation. The nanopaticulation of GC enhanced the GC presentation on CD1d of antigen presenting cells, NKT proliferation, IFN-gamma production, therapeutic effect against highly malignant B16 melanoma. These results strongly indicate that the nanopaticulation of GC by R8-Lip is promising technique for achieving systemic GC therapy.
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