2014 Fiscal Year Final Research Report
Novel molecular mechanism of neuronal functions by ERK5
| Project/Area Number |
24790063
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biological pharmacy
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| Research Institution | Yamagata University |
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Principal Investigator |
OBARA YUTARO 山形大学, 医学部, 准教授 (40400270)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 神経栄養因子 / NGF / ERK5 / MAPK |
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| Outline of Final Research Achievements |
We have indentified many genes regulated by ERK5 selectively. Among them, we focused on p36 and examined its roles. We found that p36 stabilized catecholamine-synthesizing enzyme, tyrosine hydroxylase, and promoted its biosynthesis. Hence, it is assumed that ERK5 and p36 play roles in strength of the neuronal functions during the neuronal differentiation.
In addition, we found that ERK1/2 phosphorylated ERK5 Thr732 and promoted nuclear translocation of ERK5. We could clarify the novel cross-talk mechanism between ERK5 and ERK1/2.
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| Free Research Field |
薬理学
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