2013 Fiscal Year Final Research Report
Molecular network of virulence factors in resident bacteria for infection against diabetic host
| Project/Area Number |
24790069
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biological pharmacy
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | 細菌学 / 感染症 / 糖尿病 / 病原性遺伝子 / カイコ / ヘム取り込み / N-アセチルグルコサミン / 黄色ブドウ球菌 |
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| Research Abstract |
Diabetic patients are sensitive to infection caused by resident bacteria. However, molecular mechanisms of the resident bacteria for causing severe infectious diseases against diabetic patients are still unknown. In this study, we identified three genes, which were required for virulence of Staphylococcus aureus (S. aureus) against hyperglycemic silkworms. Our findings suggest that bacteria possess specific system for infection against diabetic patients.
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