2013 Fiscal Year Final Research Report
The metabolic activation and the structural requirement in the allergic reactions of drugs and environmental chemicals
| Project/Area Number |
24790126
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Environmental pharmacy
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| Research Institution | Nihon Pharmaceutical University |
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Principal Investigator |
URAMARU NAOTO 日本薬科大学, 薬学部, 講師 (90424069)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | 薬物アレルギー / 環境化学物質 / 代謝的活性化 |
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| Research Abstract |
Allergic contact dermatitis is a drug allergic reaction characteristically caused by application of allergenic low-molecular-weight chemicals to the skin. A purpose of this study is to determined contribution of metabolic activation and a factor of chemical structure in the drug allergic reaction. We determined a metabolic reaction in in vitro of parabens and benzophenones used as a food preservative and ultraviolet absorber. Furthermore, we found the histamine release from rat peritoneal mast cell activities changed by various kinds of parabens. Adequate bulky alkyl side chain of parabens is required for the allergic reactions.
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[Journal Article] Comparative study of the hydrolytic metabolism of methyl-, ethyl-, propyl-, butyl-, heptyl- and dodecylparaben by microsomes of various rat and human tissues2013
Author(s)
Ozaki H., Sugihara K., Watanabe Y., Fujino C., Uramaru N., Sone T., Ohta S., Kitamura S
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Journal Title
Xenobiotica
Volume: 43(12)
Pages: 1064-1072
DOI
Peer Reviewed
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[Journal Article] Similarities in the endocrine-disrupting potencies of indoor dust and flame retardants by using human osteosarcoma (U2OS) cell-based reporter gene assays2013
Author(s)
Suzuki G., Tue N.M., Malarvannan G., Sudaryanto A., Takahashi S., Tanabe S., Sakai S., Brouwer A., Uramaru N., Kitamura S., Takigami H
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Journal Title
Environ Sci Technol
Volume: 47(6)
Pages: 2898-908
DOI
Peer Reviewed
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[Journal Article] Predictability of metabolism of Ibuprofen and naproxen using chimeric mice with human hepatocytes2012
Author(s)
Sanoh S., Horiguchi A., Sugihara K., Kotake Y., Tayama Y., Uramaru N., Ohshita H., Tateno C., Horie T., Kitamura S., Ohta S
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Journal Title
Drug Metab Dispos
Volume: 40(12)
Pages: 2267-72
DOI
Peer Reviewed
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