2014 Fiscal Year Final Research Report
Effects of immune-complex formation on the biological activities of anti-TNFalpha monoclonal antibody products
| Project/Area Number |
24790183
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Medical pharmacy
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| Research Institution | National Institute of Health Sciences |
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Principal Investigator |
TADA Minoru 国立医薬品食品衛生研究所, 生物薬品部, 室長 (50506954)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 抗体医薬品 / TNFα |
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| Outline of Final Research Achievements |
To reveal the differences in the biological activities of anti-TNFα monoclonal antibody products, effects of immune-complex formation on their biological activities were examined. The molecular sizes of immune-complex formed by TNFα and anti-TNFα monoclonal antibodies were different in each antibody. FcγR reporter cell assay showed that the activations of FcγR by each antibody were dependent on the size of immune-complex. These results suggest that the difference in the formation of immune-complex is an important property characterizing anti-TNFα monoclonal antibody products.
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| Free Research Field |
生物薬品学
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