2013 Fiscal Year Final Research Report
Analysis of molecular mechanisms underlying regulation of basal activity of t-tubular L-type Ca channels in ventricular myocytes
| Project/Area Number |
24790210
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
General physiology
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| Research Institution | Shinshu University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | L型カルシウムチャネル / 心筋 / タンパク質リン酸化酵素 / 心不全 / T管 / 興奮収縮連関 |
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| Research Abstract |
Despite recently advanced medical therapies, heart failure is one of the leading risks of death in developed nations. T-tubular L-type Ca2+ channels (LTCC) in ventricular myocytes play a crucial role in cardiac excitation-contraction coupling. Decreased basal activity of t-tubular LTCC is involved in cardiac disfunction. We recently found that basal activity of LTCC is supported by casein kinase 2 (CK2). Here, I examined the molecular mechanisms underlying regulation of basal LTCC activity by CK2. In the result, I found that CK2a'b determines the basal activity of cardiac LTCC.
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