2013 Fiscal Year Final Research Report
Vagal afferent-mediated coupling of peripheral factor sensing to brain transmission and feeding regulation
| Project/Area Number |
24790221
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
General physiology
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| Research Institution | Jichi Medical University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | 求心性迷走神経 / nodose ganglion / 摂食 / insulin / pancreatic polypeptide / peptide YY / oxytocin / DNA microarray |
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| Research Abstract |
Vagal afferents sense the peripheral factors, convey this neural information to the brain, thereby regulating feeding. However, it is not clear that what kinds of factors act on the vagal afferents directly and what kinds of neurotransmitters which are released from the vagus terminals to the nucleus tractus solitaries (NTS) contribute to regulate food intake.
The present study demonstrates that insulin, pancreatic polypeptide, peptide YY3-36, and oxytocin directly act on the isolated vagal afferent neurons, and these effects are participated in decreasing food intake. CART peptide is putative neurotransmitter to decrease food intake, which is released from vagus terminals to NTS. Moreover, 12 genes in the NG changed the expression level more than twice between fasting and satiety, but it remains to be determined whether these gene-related molecules regulate food intake.
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[Journal Article] Insulin activates vagal afferent neurons including those innervating pancreas via insulin cascade and Ca^<2+> influx : Its dysfunction in IRS2-KO mice with hyperphagic obesity2013
Author(s)
Iwasaki, Y., Shimomura, K., Kohno, D., Dezaki, K., Ayush. EA., Nakabayashi, H., Kubota, N., Kadowaki, T., Kakei, M., Nakata, M., and Yada, T
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Journal Title
PLoS One
Volume: 8(6)
Pages: e67198
DOI
Peer Reviewed
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[Journal Article] Pancreatic polypeptide and peptide YY_<3-36>induce Ca^<2+> signaling in nodose ganglion neurons2013
Author(s)
Iwasaki, Y., Kakei, M., Nakabayashi, H., Ayush, EA., Hirano-Kodaira, M., Maejima, Y. and Yada, T
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Journal Title
Neuropeptides
Volume: 47
Pages: 19-23
DOI
Peer Reviewed
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