2013 Fiscal Year Final Research Report
The role of cyclophilin A in diabetic vascular calcification
| Project/Area Number |
24790254
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
General pharmacology
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| Research Institution | The University of Tokushima |
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Principal Investigator |
ISHIZAWA Yuki 徳島大学, ヘルスバイオサイエンス研究部, 助教 (40610192)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | 心血管・血液 / 糖尿病 / 血管石灰化 / 酸化ストレス |
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| Research Abstract |
Arterial calcification is accompanied by several cardiovascular diseases such as atherosclerosis, diabetes mellitus, and renal failure. Osteogenic differentiation of vascular smooth muscle cell (VSMC) plays important role in vascular calcification. It was observed that the inorganic phosphate (Pi) increased rho-kinase activation which is reported to be involved in the autocrine of cyclophilin A, alkaline phosphatase (ALP) activity, and calcium accumulation in cultured VSMCs. The pretreatment with rho-kinase inhibitor inhibited Pi-induced ALP activity and calcium accumulation. From these results, it was suggested that rho-kinase activation and the autocrine of cyclophilin A might be related with Pi-induced vascular calcification.
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