2013 Fiscal Year Final Research Report
Control mechanism of hydrogen sulfide producing enzyme by phosphorylation
| Project/Area Number |
24790263
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
General pharmacology
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| Research Institution | Showa Pharmaceutical University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | 含硫アミノ酸代謝酵素 / リン酸化修飾 / 翻訳後修飾 |
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| Research Abstract |
We investigated control mechanism of sulfur-containing amino acid metabolic enzyme, cystathionine beta-synthase (CBS), cystathionine gamma-lyase and 3-mercaptopyruvate sulfurtransferase by phosphorylation. We found that CBS is phosphorylated by protein kinases. These data indicate that CBS might be controlled by its phosphorylation.
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[Journal Article] Reactive cysteine persulfides and S-polythiolation regulate oxidative stress and redox signaling2014
Author(s)
Ida T, Sawa T, Ihara H, Tsuchiya Y, Watanabe Y, Kumagai Y, Suematsu M, Motohashi H, Fujii S, Matsunaga T, Yamamoto M, Ono K, Devarie-Baez N. O, Xian M, Fukuto J. M, Akaike T
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Journal Title
Proc. Natl. Acad. Sci. U. S. A.
Volume: (In press)
DOI
Peer Reviewed
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