2013 Fiscal Year Final Research Report
Development of a new method to induce cardiomyocytes from pluripotent stem cells in vivo for regenerative cell therapy.
| Project/Area Number |
24790277
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
General medical chemistry
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | 再生医学 |
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| Research Abstract |
We compared the grafting efficiency of undifferentiated cell, early mesodermal cells, cardiomyocytes (early- and middle-stage) from human iPS cells in transplantation into mouse hearts, and found that middle-stage differentiated cardiomyocytes can be grafted efficiently. We also observed that transplanted differentiated cardiomyocytes can survive and maturate in the infarcted mouse hearts and improve the cardiac function.
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Research Products
(24 results)
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[Journal Article] A novel efficient feeder-free culture system for the derivation of human induced pluripotent stem cells2014
Author(s)
Nakagawa M, Taniguchi Y, Senda S, Takizawa N, Ichisaka T, Asano K, Morizane A, Doi D, Takahashi J, Nishizawa M, Yoshida Y, Toyoda T, Osafune K, Sekiguchi K, and Yamanaka S
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Journal Title
Scientific Reports, laVT
Volume: 4
Pages: 3594
DOI
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[Journal Article] Ultrastructural Maturation of Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes in a Long-Term Culture2013
Author(s)
Kamakura T, Makiyama T, Sasaki K, Yoshida Y, Wur i yangha i Y, Chen J, Hattori T, Ohno S, Kita T, Horie M, Yamanaka S, and Kimura T
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Journal Title
Circulation Journal, V ak 4T
Volume: 77 (5)
Pages: 1307-1314
DOI
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