2013 Fiscal Year Final Research Report
Analysis of the effects of hypoxia inducible factor for tumor metastasis
| Project/Area Number |
24790308
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pathological medical chemistry
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| Research Institution | University of Tsukuba |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | 分子腫瘍学 / 低酸素応答 / 血管内皮細胞 / がん微小環境 |
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| Research Abstract |
Hypoxia inducible transcription factor (HIF) has various physiological functions. The results of the HIF functional analysis in vascular endothelial cells with tail vein injection metastasis model, we found that metastasis foci was reduced when transplanted into HIF-2alpah knockdown host mice. HIF-2alpa knockdown mice have low activities in HIF-2alpha in endothelial cells. Furthemore, HIF-3alpha acting on inhibitory to the hypoxic response is controlling to the inhibitory VE-cadherin expression in pulmonary vascular endothelial cells. We found the phenomenon that HIF-1apha is activated in compensatory when HIF-2alpha was reduced to a certain level below threshold.
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[Journal Article] Deficiency of NOXl/nicotinamide adenine dinucleotide phosphate,reduced form oxidase leads to pulmonary vascular remodeling2014
Author(s)
Iwata K,Ikami K,Matsuno K,Yamashita T,Shiba D,Ibi M,Matsumoto M,Katsuyama M,Cui W,Zhang J,Zhu K,Takei N,Kokai Y,Ohneda O,Yokoyama T,Yabe,. Nishimura C
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Journal Title
Arterioscler Thromb Vasc Biol
Volume: 34(l)
Pages: ll0-9
DOI
Peer Reviewed
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Author(s)
Fukuda S,Nagano M,Yamashita T,Kimura K,Tsuboi I,Salazar G,Ueno S,Kondo M,Kunath T,Oshika T,Ohneda O
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Journal Title
Stem Cells
Volume: 3l(l0)
Pages: 2l49-6l
DOI
Peer Reviewed
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