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2013 Fiscal Year Final Research Report

Role of SPAL-1 in higher brain function and molecular mechanism of psychiatric diseases

Research Project

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Project/Area Number 24790311
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Pathological medical chemistry
Research InstitutionThe University of Tokyo

Principal Investigator

MATSUURA Ken  東京大学, 分子細胞生物学研究所, 助教 (10625742)

Project Period (FY) 2012-04-01 – 2014-03-31
Keywords神経科学
Research Abstract

SPAL-1 is a neuronal protein abundantly expressed in excitatory synapses. However, its physiological function is poorly understood. We have previously shown that SPAL-1 KO mice exhibit intellectual disabilities and autism-like behaviors, which suggest an important role of SPAL-1 in higher brain function. In this research, we further attempted to elucidate molecular mechanism involving SPAL-1. We performed comprehensive screening of physiological interactants of SPAL-1 in mouse forebrain using IP-MS analysis. SPAL-1 was cross-linked to the adjacent proteins prior to cell lysis to preserve the original complex and avoid artificial binding in the later procedures. Sample from SPAL-1 KO mice was used as negative control. As a result, we have identified several promising interactants such as endocytotic factors and subunits of sodium-potassium pump, that may lead to an elucidation of the molecular function of SPAL-1 in the brain.

  • Research Products

    (2 results)

All 2012

All Presentation (2 results)

  • [Presentation] Regulation of cell fusion through Wnt signaling Novel insight into cell fusion biology2012

    • Author(s)
      Ken Matsuura, Takafumi Jigami, Kenzui Taniue, Yasuyuki Morishita, Shungo Adachi, Takao Senda, Hiroyuki Aburatani, Tsutomu Nakamura, Tetsu Akiyama
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      福岡
    • Year and Date
      2012-12-12
  • [Presentation] Identification of a link between Wnt /β-catenin signaling and the cell fusion pathway EMBO Conference2012

    • Author(s)
      Ken Matsuura, Takafumi Jigami, Kenzui Taniue, Yasuyuki Morishita, Shungo Adachi, Takao Senda, Hiroyuki Aburatani, Tsutomu Nakamura, Tetsu Akiyama
    • Organizer
      30 Years of Wnt Signaling
    • Place of Presentation
      オランダ
    • Year and Date
      2012-06-29

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Published: 2015-06-25  

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