2013 Fiscal Year Final Research Report
Functions of Mob1A/1B in development and oncogenesis
| Project/Area Number |
24790319
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Pathological medical chemistry
|
|---|
| Research Institution | Kyushu University |
|---|
Principal Investigator |
NISHIO Miki 九州大学, 生体防御医学研究所, 助教 (10467897)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
SUZUKI Akira 九州大学, 生体防御医学研究所, 教授 (10311565)
ITAMI Satoshi 大阪大学, 大学院医学系研究科, 教授 (30136791)
MIZUNO Kensaku 東北大学, 大学院生命科学研究科, 教授 (70128396)
CHIBA Syuhei 大阪大学, 大学院生命科学研究科, 特任助教 (60572493)
|
|---|
| Project Period (FY) |
2012-04-01 – 2014-03-31
|
| Keywords | 発癌 / Mob1 / シグナル伝達 / 発生 |
|---|
| Research Abstract |
The Hippo pathway is evolutionarily conserved, and the vertebrate Hippo pathway has been implicated in regulating cell contact inhibition, organ size, and tumorigenesis. The Mob1A/1B are the binding partners and strong co-activators of Lats kinases family, and the members of the Hippo pathway.However, the normal functions of Mob1A/1B proteins in vivo had been unknown.To define the functions of mammarian Mob1A/1B, we generated Mob1A and 1B null mutant mice. We showed Mob1A/1B double homozygous mutant mice died at gastrulation.Thus, Mob1A/B is essential for murine embryogenesis. Partially mutants developed a variety of tumors. Moreover, half of human trichilemmal carcinoma samples showed Mob1A/1B inactivation and YAP activation.These observations suggest that the loss of Hippo signaling molecules can be an important driver of cancer progression.
|
-
[Journal Article] The expression of PTEN in the development of mouse cochlear lateral wall2014
Author(s)
①Dong Y, Sui L, Yamaguchi F, Kamitori K, Hirata Y, Hossain MA, Noguchi C, Katagi A, Nishio M, Suzuki A, Tokuda M
-
Journal Title
Neuroscience
Volume: 258(1)(Epub 2013 Nov 16)
Pages: 263-9
DOI
Peer Reviewed
-
-
[Journal Article] Cancer susceptibility and embryonic lethality in Mob1a/1b double - mutant mice2012
Author(s)
③Nishio M, Hamada K, Kawahara K, Sasaki M, Noguchi F, Chiba S, Mizuno K, Suzuki SO, Dong Y, Tokuda M, Morikawa T, Hikasa H, Eggenschwiler J, Yabuta N, Nojima H, Nakagawa K, Hata Y, Nishina H, Mimori K, Mori M, Sasaki T, Mak TW, Nakano T, Itami S, Suzuki A
-
Journal Title
J. Clin. Invest
Volume: 122(12)
Pages: 4505-18
DOI
Peer Reviewed
-
-
-
-
-
-
-
-
-
