Approach to identify genetic susceptibility to lung adenocarcinoma with EGFR mutation

2013 Fiscal Year Final Research Report

• Project/Area Number: 24790340
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Human genetics
• Research Institution: National Center of Neurology and Psychiatry
• Principal Investigator: SHIRAISHI Kouya 独立行政法人国立がん研究センター, 研究所, 研究員 (80609719)
• Project Period (FY): 2012-04-01 – 2014-03-31
• Keywords: 肺腺がん / 遺伝子多型 / 全ゲノム関連解析

Research Abstract

Advanced in genome research, it has become clear that the frequency of ADC with EGFR mutation was different between Asian and Caucasian. Therefore, genetic factors involved in susceptibility to ADC with EGFR mutation might be different by ethnicity or genetic background. To identify new susceptibility loci in ADC with EGFR mutation, we performed a genome-wide association study of ADC with EGFR mutation consisted of 663 cases from National cancer center hospital and 4,365 controls from Bio-bank Japan. In the GWAS, previously reported loci with ADC risk (TERT, TP63, BPTF and BTNL2) were also associated with risk for ADC with EGFR mutation. We detected EGFR mutation in DNA samples extracted from lung cancer tissues using HRMA. Further studies of putative susceptibility loci in several replication sets will need to identify new susceptibility to ADC with EGFR mutation.

Research Products

• [Journal Article] Regulatory nexus of synthesis and degradation deciphers cellular Nrf2 expression levels (2013)
  • Author(s): Suzuki T, Shibata T, Takaya K, Shiraishi K, Kohno T, Kunitoh H, Tsuta K, Furuta K, Goto K, Hosoda F, et al
  • Journal Title: Molecular and cellular biology Volume: 33(12) Pages: 2402-2412
  • DOI: 10.1128/MCB.00065-13
  • Peer Reviewed
• [Journal Article] A genome - wide association study identifies two new susceptibility loci for lung adenocarcinoma in the Japanese population (2012)
  • Author(s): Shiraishi K, Kunitoh H, Daigo Y, Takahashi A, Goto K, Sakamoto H, Ohnami S, Shimada Y, Ashikawa K, Saito A, et al
  • Journal Title: Nature genetics Volume: 44(8) Pages: 900-903
  • DOI: 10.1038/ng.2353
  • Peer Reviewed
• [Presentation] Genetic factors related with lung adenocarcinoma (2013)
  • Author(s): Shiraishi K, Kunitoh H, Daigo Y, Takahashi A, Goto K, Sakamoto H, Ohnami S, Shimada Y, Ashikawa K, Saito A, Watanabe S, Tsuta K, Kamatani N, Yoshida T, Nakamura Y, Yokota J, Kubo M, Kohno T
  • Organizer: 日本癌学会
  • Place of Presentation: 横浜
  • Year and Date: 20130000
• [Presentation] A genome - wide association study identifies two new susceptibility loci for lung adenocarcinoma in the Japanese population (2012)
  • Author(s): Shiraishi K, Kunitoh H, Daigo Y, Takahashi A, Goto K, Sakamoto H, Ohnami S, Shimada Y, Ashikawa K, Saito A, Watanabe S, Tsuta K, Kamatani N, Yoshida T, Nakamura Y, Yokota J, Kubo M, Kohno T
  • Organizer: An AACR Special Conference on Post - GWAS horizons in molecular epidemiology
  • Place of Presentation: Hollywood, FL, USA
  • Year and Date: 20120000
• [Presentation] A genome- wide association study identifies two new susceptibility loci for lung adenocarcinoma in the Japanese population (2012)
  • Author(s): Shiraishi K, Kunitoh H, Daigo Y, Goto K, Sakamoto H, Yoshida T, Nakamura Y, Yokota J, Kohno T
  • Organizer: 日本癌学会
  • Place of Presentation: 札幌
  • Year and Date: 20120000
• [Remarks] 独立行政法人国立がん研究センター研究所 ゲノム生物学研究分野ホームページ
  • URL: http://www.ncc.go.jp/jp/nccri/divisions/genome_biology/