2013 Fiscal Year Final Research Report
Pathological significans of CD169-positive macrophages in colorectal cancer patients
| Project/Area Number |
24790353
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Human pathology
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| Research Institution | Kumamoto University |
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Principal Investigator |
OHNISHI Koji 熊本大学, 生命科学研究部, 助教 (40613378)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | CD169 / マクロファージ / リンパ節 / 大腸癌 / 腫瘍免疫 / バイオマーカー |
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| Research Abstract |
Previous CD169 studies were mainly performed with rodents; only a few studies described CD169 expression in humans. In this study, to examine the role of CD169 in human diseases, we focused on CD169+ sinus macrophages in regional lymph nodes (RLNs) of patients with colorectal carcinoma (CRC). We examined the expression of CD169 in regional lymph nodes (RLNs) and their relations with overall survival in CRC. In a clinicopathological analysis on 83 CRC patients, paraffin-embedded specimens were evaluated for CD169 expression of RLN macrophages by immunohistochemistry. We found a high density of CD169+ macrophages was significantly associated with longer overall survival. We also found that the density of CD169+ macrophages had a positive correlation with the number of CD8+ cytotoxic T cells infiltrating tumor tissues. These data suggest that CD169+ macrophages in RLNs promote CD8+ T-cell-mediated anti-tumor immunity and are associated with a better prognosis for CRC patients.
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[Presentation]2013
Author(s)
Koji Ohnishi, Yoshihiro Komohara, Yoichi Saito, Yui Hayashida, Takenobu Nakagawa, Motohiro Takeya
Organizer
5th EMBO Workshop
Place of Presentation
Marseille, France, Centred' Immunologie Marseille-Luminy
Year and Date
20130114-19
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