2013 Fiscal Year Final Research Report
Mechanism of protective immunity against blood-stage malaria by CD8T cells.
| Project/Area Number |
24790399
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Parasitology (including Sanitary zoology)
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| Research Institution | Gunma University |
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Principal Investigator |
IMAI Takashi 群馬大学, 医学(系)研究科(研究院), 助教 (10513434)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | マラリア / CD8 / マラリア原虫 / マクロファージ / 感染防御 / T細胞 / 赤芽球 |
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| Research Abstract |
Mice depleted of CD8 T cells showed higher parasitemia and lower survival during infection with otherwise non-lethal blood-stage malaria parasites, indicating protective roles of CD8 T cells. However, how these cells mediate protection to blood-stage malaria parasites that infect red blood cells deficient in MHC class I expression is elusive. In this study, we found that erythroblasts, progenitor cells of red blood cells, are parasitized by malaria parasites, and parasitized erythroblasts were recognized by CD8 T cells in an antigen-specific manner, suggesting that parasitized erythroblasts are the target of CD8 T cell. We further explored protective mechanisms exerted by CD8 T cells. We revealed that phosphatidylserine was externalized on parasitized cells after a ligation of cytotoxic molecule FasL on CD8 T cells to Fas on the target cells, which leads to induce effective phagocytosis by macrophages.
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Research Products
(15 results)
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[Journal Article] Resistance to Malaria by Enhanced Phagocytosis of Erythrocytes in LMP7-deficient Mice2013
Author(s)
Xuefeng Duan, Takashi Imai, Bin Chou, Liping Tu, Kunisuke Himeno, Kazutomo Suzue, Makoto Hirai, Tomoyo Taniguchi, Hiroko Okada, Chikako Shimokawa, Hajime Hisaeda
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Journal Title
PloS one
Volume: 8(3)
Pages: e59633
DOI
Peer Reviewed
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